The ultrastructural pathology of sulfur mustard gas (HD) skin toxicity has been documented for several model systems. In animal models, development of skin basal cell nuclear pathology was followed by progressive cytoplasmic changes leading to cell death. These cellular changes along with a disabling of hemidesmosomes at the lamina lucida were persistent features leading to the formation of characteristic microblisters at the dermal-epidermal junction.In this paper we correlate an ultrastructural pathologic study of HD exposed hairless guinea pig skin with a companion immunohistochemical study describing HD effects on extra-cellular structural proteins of the dermal-epidermal junction. The structural proteins summarized for this report are bullous pemphigoid antigen and laminin.
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Petrali et al. (1992) studied this question.
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