Key result
Among patients with open-angle glaucoma, feeling stressed was a significant predictor of higher severity of depression (OR 9.47).
Why the study?
Glaucoma damages the optic nerve and may interconnect with psychoneurotic disorders from chronic disease-related stress; the study examined anxiety, depression, and open-angle glaucoma characteristics.
Cross-Sectional (n=200)
No
Odds Ratio: 9.47 (95% CI 4.75–19.59)
p-value: p=<0.001
Older age, female gender, and perceived stress are significant predictors of anxiety and depression in patients with open-angle glaucoma.
Anxiety/depression in OAG patients associate with female sex, older age and stress, not stage; leaves open need for targeted screening trials.
Background: Glaucoma is a group of eye conditions that damage the optic nerve, and it can be interconnected with psychoneurotic disorders due to the psychological and emotional stress that comes with such a chronic condition. The aim of this study was to examine the characteristics of the occurrence of anxiety, depression and open-angle glaucoma (OAG) in glaucoma patients from December 2023 to December 2024. Methods: This cross-sectional study was conducted on 200 patients with three different stages of OAG. Multiple questionnaires were used to determine the influence of different OAG stages on the severity of anxiety and depression. Results: While predicting the anxiety expression, in a multivariate logistic regression (stepwise method), there was a significant model in predicting the expression of anxiety: female gender (Odds ratio (OR) = 3.03), age of 66 and over (OR = 3.4) and the feeling of being under stress (OR = 7.07). In the prediction of a higher severity of depression, predictors are age 66 and older (OR = 2.03) and feeling stressed (OR = 9.47). Conclusions: While glaucoma and psychoneurotic disorders affect different systems in the body, the psychological toll of living with glaucoma can lead to exacerbation of glaucoma.
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Olujić et al. (2025) conducted a cross-sectional in Open-angle glaucoma (n=200). Feeling stressed vs. Not feeling stressed was evaluated on Higher severity of depression (PHQ-9) (OR 9.47, 95% CI 4.75-19.59, p=<0.001). Among patients with open-angle glaucoma, feeling stressed was a significant predictor of higher severity of depression (OR 9.47).
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