Key result
Propylene glycol linearly increased blood glucose and insulin and decreased BHBA and NEFA during feed restriction, with a 296 ml dose being nearly as effective as 887 ml.
Why the study?
Does propylene glycol dosage reduce lipid mobilization in prepartum Holstein heifers during feed restriction?
Population
8 Holstein heifers, averaging 90 days prior to calving, undergoing restricted feed intake (50% of ad libitum)
Comparison
Oral drench of 296, 592, or 887 ml of propylene… vs 0 ml of propylene glycol (control) once daily
Design
Preclinical, 4 x 4 Latin square design
Follow-up
12-day periods
Authors
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Low-dose propylene glycol may blunt lipid mobilization in feed-restricted prepartum heifers; leaves open dose optimization and clinical translation in dairy cattle.
RCT (n=8)
4 x 4 Latin square
Does propylene glycol dosage reduce lipid mobilization in prepartum Holstein heifers during feed restriction?
A low dose of propylene glycol (296 ml) is nearly as effective as higher doses in reducing lipid mobilization in feed-restricted prepartum heifers.
Grummer et al. (1994) conducted an RCT in Restricted feed intake in prepartum heifers (n=8). Propylene glycol vs. 0 ml was evaluated on Plasma NEFA, glucose, insulin, and BHBA concentrations. Propylene glycol linearly increased blood glucose and insulin and decreased BHBA and NEFA during feed restriction, with a 296 ml dose being nearly as effective as 887 ml.
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