Key result
IABP coupled with CRT resulted in significant acute improvements in aortic pressure, PCWP, and V-wave amplitude compared with baseline and IABP alone in two patients with refractory heart failure.
Why the study?
Does IABP coupled with CRT improve acute haemodynamics in patients with refractory systolic heart failure?
Case Report (n=2)
Does IABP coupled with CRT improve acute haemodynamics in patients with refractory systolic heart failure?
The combination of IABP and CRT provides significant acute haemodynamic improvement in patients with refractory systolic heart failure, suggesting a potential bridging strategy.
Should not change practice from two cases; leaves open whether IABP+CRT offers a viable acute bridge in refractory HF.
We report two cases in which intra-aortic balloon pump (IABP) was used successfully as a bridge to cardiac resynchronization therapy (CRT) to treat patients with refractory systolic heart failure. The study was designed to assess the acute haemodynamic effects of IABP coupled with CRT using standard haemodynamic monitoring. In both cases, a marked elevation of V-wave in pulmonary capillary wedge pressure (PCWP) was shown, and a moderate-to-severe functional mitral regurgitation was observed. IABP and CRT resulted in a significant acute improvement in aortic pressure, PCWP, and V-wave amplitude compared with baseline measurements and IABP alone. These results provide a basis for studies examining the haemodynamic effects of IABP support associated with CRT in patients with heart failure refractory to medical therapy.
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Bonanno et al. (2008) conducted a case report in Refractory systolic heart failure (n=2). Intra-aortic balloon pump (IABP) coupled with cardiac resynchronization therapy (CRT) vs. Baseline measurements and IABP alone was evaluated on Acute haemodynamic effects (aortic pressure, PCWP, and V-wave amplitude). IABP coupled with CRT resulted in significant acute improvements in aortic pressure, PCWP, and V-wave amplitude compared with baseline and IABP alone in two patients with refractory heart failure.
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