Key result
A lower pre-awakening heart rate surge was associated with higher left ventricular mass index and an increased risk of death (HR 0.89 per 1 unit; 95% CI 0.83-0.96; P=0.001) in hemodialysis patients.
Why the study?
Exaggerated early morning increases in BP and HR indicate high cardiovascular risk, but early morning changes in these parameters had not been investigated in hemodialysis patients.
Are early morning hemodynamic changes associated with left ventricular hypertrophy and mortality in hemodialysis patients?
Population
58 hemodialysis patients
Comparison
Pre-awakening BP and HR surges, nocturnal dipping, and weighted 24 h systolic BP and HR variability
Design
Pilot single center study
Follow-up
Median follow up of 40 months
Authors
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Early morning BP/HR surges in hemodialysis patients remain uncharacterized; this pilot study leaves open their prognostic value and autonomic links.
Cohort (n=58)
No
Are early morning hemodynamic changes associated with left ventricular hypertrophy and mortality in hemodialysis patients?
Hazard Ratio: 0.89 (95% CI 0.83–0.96)
p-value: p=0.001
Low early morning changes in heart rate, likely reflecting enhanced sympathetic activity, are associated with a higher risk of left ventricular hypertrophy and mortality in hemodialysis patients.
Mallamaci et al. (2022) conducted a cohort in Hemodialysis (n=58). Pre-awakening heart rate surge was evaluated on Left ventricular mass index (LVMI) and risk of death (HR 0.89, 95% CI 0.83-0.96, p=0.001). A lower pre-awakening heart rate surge was associated with higher left ventricular mass index and an increased risk of death (HR 0.89 per 1 unit; 95% CI 0.83-0.96; P=0.001) in hemodialysis patients.
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