Key result
Undifferentiated pleomorphic sarcoma tumors ≥ 8 cm exhibited a significantly higher intratumoral neutrophil-to-lymphocyte ratio (0.32 vs 0.10) and decreased CD8+ effector T-cell infiltration compared to tumors < 8 cm.
Why the study?
Understanding of how the tumor microenvironment correlates to clinicopathologic parameters such as tumor size and depth in undifferentiated pleomorphic sarcoma remains limited.
Does tumor morphology and location correlate with immune cell composition in undifferentiated pleomorphic sarcoma?
Population
15 freshly resected UPS tumors from a prospective and retrospective cohort of UPS patients
Design
Single-cell flow cytometric immune profiling with prospective and retrospective cohort analysis
Authors
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Larger UPS tumors associate with fewer CD8+ TILs and worse survival; leaves open whether immune profiling augments size-based risk stratification.
Observational (n=15)
No
Does tumor morphology and location correlate with immune cell composition in undifferentiated pleomorphic sarcoma?
Absolute Event Rate: 0.32% vs 0.1%
p-value: p=<0.00001
Tumor size and depth in undifferentiated pleomorphic sarcoma correlate with specific immune cell compositions in the tumor microenvironment, which may have prognostic implications.
Wustrack et al. (2021) conducted an observational in Undifferentiated pleomorphic sarcoma (UPS) (n=15). Tumor size ≥ 8 cm vs. Tumor size < 8 cm was evaluated on Intratumoral neutrophil-to-lymphocyte ratio (NLR) (p=<0.00001). Undifferentiated pleomorphic sarcoma tumors ≥ 8 cm exhibited a significantly higher intratumoral neutrophil-to-lymphocyte ratio (0.32 vs 0.10) and decreased CD8+ effector T-cell infiltration compared to tumors < 8 cm.
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