Key result
De novo preeclampsia was associated with higher risks of liver impairment and cesarean delivery (p<0.05), whereas superimposed preeclampsia was associated with poorer fetal outcomes (p<0.05).
Why the study?
Does de novo preeclampsia compared to superimposed preeclampsia result in different maternal and fetal outcomes in pregnant women?
Observational (n=164)
No
Does de novo preeclampsia compared to superimposed preeclampsia result in different maternal and fetal outcomes in pregnant women?
p-value: p=< 0.05
De novo preeclampsia is associated with higher risks of liver impairment and cesarean delivery, whereas superimposed preeclampsia carries higher risks of adverse fetal outcomes and maternal renal/ECG complications.
Supports subtype-specific surveillance in hypertensive pregnancies; leaves open whether targeted strategies improve maternal-fetal outcomes.
AIM: To assess the maternal and fetal outcome in women with de novo preeclampsia (PE) in comparison to superimposed PE. STUDY DESIGN: This was a prospective 2-year observational study carried out at Menoufia University Hospital, Egypt, in which 164 patients out of 6472 pregnant women were diagnosed with PE (78 with de novo PE and 86 with superimposed PE). Enrolled patients were followed to assess the maternal and fetal outcome. RESULTS: There was a significant higher women with liver impairment and delivery by caesarean section in the de novo PE group (p < 0.05), with more women with renal impairment and ECG changes in the superimposed PE group (p < 0.05). No significant difference between the two groups regarding the occurrence of eclampsia, blood transfusion, admission to ICU and venous thromboembolism (p > 0.05). There was a significantly higher small for gestational age, prematurity, NICU admission and perinatal mortality in the superimposed PE group (p < 0.05). No significant difference between the two groups regarding the occurrence of placental abruption and intrauterine fetal demise (p > 0.05). CONCLUSIONS: Women with de novo PE have higher risks of liver impairment and delivery by cesarean section. On the other hand, women with superimposed PE have higher risks of poorer fetal outcome.
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Rezk et al. (2014) conducted an observational in Preeclampsia (n=164). De novo preeclampsia vs. Superimposed preeclampsia was evaluated on Maternal and fetal outcomes (p=< 0.05). De novo preeclampsia was associated with higher risks of liver impairment and cesarean delivery (p<0.05), whereas superimposed preeclampsia was associated with poorer fetal outcomes (p<0.05).
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