Key result
Preeclampsia superimposed on chronic hypertension was associated with a significantly higher rate of neonatal complications (39.29% vs 13.45%) compared to preeclampsia alone.
Why the study?
Does preeclampsia superimposed on chronic hypertension result in worse maternal and perinatal outcomes compared to preeclampsia alone in pregnant women?
Cohort (n=850)
No
Does preeclampsia superimposed on chronic hypertension result in worse maternal and perinatal outcomes compared to preeclampsia alone in pregnant women?
Absolute Event Rate: 39.29% vs 13.45%
p-value: p=<0.001
Preeclampsia superimposed on chronic hypertension is associated with higher risks of adverse perinatal outcomes, such as neonatal respiratory distress syndrome and intracranial hemorrhage, compared to preeclampsia alone.
May support closer perinatal monitoring in superimposed preeclampsia; leaves open causal links and generalizability pending adjusted prospective data.
AIM: The study was to determine whether preeclampsia with superimposed chronic hypertension results in worse maternal and perinatal outcomes than preeclampsia alone. MATERIALS AND METHODS: A retrospective study involving 850 pregnant women was conducted and divided into two groups: preeclampsia superimposed on chronic hypertension (group A, n = 84) and preeclampsia alone (group B, n = 766). The maternal and fetal outcomes of all subjects were collected and analyzed. RESULTS: There were no significant differences between the two groups in baseline information. However, the systolic and diastolic blood pressures in group A were significantly higher than those in group B (p < 0.05). The average interval between the onset of preeclampsia and the termination of pregnancy was significantly longer in group A as compared to group B. The incidence of serious maternal complications showed no differences between the two groups (p > 0.05). It showed a higher rate of neonatal respiratory distress syndrome and intracranial hemorrhage in group A than in group B (p < 0.05). CONCLUSIONS: Women in group A had higher risks of maternal and perinatal outcomes as compared to women in group B.
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Hu et al. (2016) conducted a cohort in Preeclampsia (n=850). Preeclampsia superimposed on chronic hypertension vs. Preeclampsia alone was evaluated on Neonatal complications (p=<0.001). Preeclampsia superimposed on chronic hypertension was associated with a significantly higher rate of neonatal complications (39.29% vs 13.45%) compared to preeclampsia alone.
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