Key result
Elevated levels of inflammatory response indices, including high-sensitivity C-reactive protein, platelet-lymphocyte ratio, leukocytes, and neutrophils, were significantly associated with an increased risk of no-reflow after PCI in patients with acute STEMI.
Why the study?
The association between changes in inflammatory response-related factors and no-reflow after PCI in patients with acute STEMI remains controversial.
Do elevated inflammatory response indices predict no-reflow after PCI in patients with acute STEMI?
Meta-Analysis (n=10,381)
Do elevated inflammatory response indices predict no-reflow after PCI in patients with acute STEMI?
Elevated inflammatory markers, including Hs-CRP, PLR, leukocytes, and neutrophils, are significant predictors of no-reflow after PCI in patients with acute STEMI.
Answers are grounded in this paper and cite their sources.
May aid pre-PCI risk stratification in STEMI; leaves open whether targeting inflammation reduces no-reflow.
BACKGROUND: After percutaneous coronary intervention (PCI), patients with acute ST-segment elevation myocardial infarction (STEMI) could have an inflammatory response, which may lead to the risk of no-reflow due to microvascular obstruction. However, the association between changes in the levels of inflammatory response-related factors and no-reflow after PCI in patients with acute STEMI is still controversial. METHODS: In this study, a meta-analysis was conducted. Studies from the database established before April 2024 were retrieved in PubMed, Web of Science, and EMBASE. Case-control or cohort studies were included. Repetitive publications, studies without full access and successful data extraction, fragmentary information, animal experiments, summary, and systematic reviews were excluded, and Review Manager 5.3 software was used to process the data. In addition, the increase of red blood cell volume width (RDW) was also a risk factor for no-reflow. CONCLUSION: Refined results of Hs-CRP, PLR, RDW, leukocytes, and neutrophil can provide clinicians with effective tools to reduce the risk of no-reflow in patients with acute STEMI after PCI.
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Le Yu (2024) conducted a meta-analysis in Acute ST-segment elevation myocardial infarction (STEMI) (n=10,381). Elevated inflammatory response indices (Hs-CRP, PLR, leukocytes, neutrophils) vs. Normal or lower levels of inflammatory response indices was evaluated on Risk of no-reflow after percutaneous coronary intervention (p=<0.001). Elevated levels of inflammatory response indices, including high-sensitivity C-reactive protein, platelet-lymphocyte ratio, leukocytes, and neutrophils, were significantly associated with an increased risk of no-reflow after PCI in patients with acute STEMI.
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