What question did this study set out to answer?

To summarize the biophysical, biochemical, and pharmacological properties of voltage-gated calcium channels in excitable tissues, focusing on the structural domains of pore-forming α1-subunits.

January 1, 1993Cellular Physiology and Biochemistry

Molecular Properties of Voltage-Dependent Ca2+ Channels in Excitable Tissues

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Key result

This review summarizes the molecular properties, physiological functions, and modulation of voltage-gated Ca2+ channels, with a focus on the structure of the ion pore-forming alpha1-subunits.

Design

Review

Authors

HGHartmut GlossmannJohannes Kepler University of Linz

Discussion

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Implication

Should not change Ca2+ channel blocker prescribing; extends molecular framework for targeted modulator development.

Key Points

To summarize the biophysical, biochemical, and pharmacological properties of voltage-gated calcium channels in excitable tissues, focusing on the structural domains of pore-forming α1-subunits.
Synthesized molecular cloning, sequence analyses, and pharmacological data characterizing calcium channel complexes across diverse cardiac, smooth muscle, and neuronal tissues.
Analyzed primary sequence domains of pore-forming α1-subunits to evaluate structural determinants of ion permeation and drug interaction.
Excitable tissues express distinct calcium channel subtypes that vary in biophysical kinetics, tissue distribution, and regulation by first and second messengers.
Primary sequence mapping of the pore-forming α1-subunits identifies discrete structural regions that dictate divalent cation selectivity and therapeutic L-type calcium channel blocker binding.

Cite This Study

Hartmut Glossmann (1993) reported a review. This review summarizes the molecular properties, physiological functions, and modulation of voltage-gated Ca2+ channels, with a focus on the structure of the ion pore-forming alpha1-subunits.

synapsesocial.com/papers/6a9f6a0024f385ca6b15d7ea https://doi.org/10.1159/000154695

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Molecular Properties of Voltage-Dependent Ca2+ Channels in Excitable Tissues

Discussion

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Implication

Key Points

Cite This Study

Molecular Properties of Voltage-Dependent Ca2+ Channels in Excitable Tissues

Discussion

Member takes

Implication

Key Points

Cite This Study

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