Key result
Multiple gene products, splice variants, and subunit assembly determine the specific activity and regulation of voltage-dependent L-type calcium channels in excitable cells.
Population
Excitable cells (basic science model for L-Type Ca channels)
Design
Review
Authors
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Channel diversity warrants cautious generalization of L-type blocker effects; leaves open isoform-selective targeting for future research.
This review provides updated molecular insights into how multiple gene products, splice variants, and subunit assembly regulate L-type calcium channel function.
Lory et al. (1991) studied this question. Multiple gene products, splice variants, and subunit assembly determine the specific activity and regulation of voltage-dependent L-type calcium channels in excitable cells.
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