Three new limonoids with high oxidation from the fruits of Aglaia edulis

This is the authors' abstract. We don't add key points for this paper.

Agledulines L-N (1 − 3), three previously undescribed limonoids with the A/D-ring-seco structural characteristics and high degree oxidation, along with the three reported compounds (4 − 6), were isolated from the fruits of Aglaia edulis. The structures of 1 − 3 were elucidated by NMR data, HRESIMS, ECD spectra, and circular dichroism exciton chirality method. The furan rings in 1 and 2 were oxidized to γ-hydroxy-butene lactone moiety, and the tautomerism of hemiacetal C-21 contributed to the disappearance of NMR signals in the segments. The biological evaluation showed that 1 − 3 had no anti-inflammatory activity by inhibiting NO release in LPS-activated RAW264.7 macrophages.