Key result
Transplantation of LIF and BMP-2 precommitted mouse embryonic stem cells improved post-MI left ventricular functions and enhanced capillary density in a mouse AMI model.
Population
Mouse embryonic stem cells (mES-D3 line) and surgically-induced mouse acute myocardial infarction (AMI) model
Comparison
Leukemia inhibitory factor and bone-morphogenic… vs Inhibitors or blocking antibodies of STAT3 or…
Design
Preclinical
Authors
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Hypothesis-generating for precommitted ESC therapy post-MI; leaves open translation to larger models and human trials.
LIF and BMP-2 synergistically promote embryonic stem cell differentiation into cardiomyocytes via STAT3 and MAPK pathways, and transplantation of these precommitted cells improves cardiac function in a mouse model of myocardial infarction.
Rajasingh et al. (2007) studied Acute myocardial infarction. LIF and BMP-2 precommitted mES cells was evaluated on CMC differentiation and post-MI left ventricular functions. Transplantation of LIF and BMP-2 precommitted mouse embryonic stem cells improved post-MI left ventricular functions and enhanced capillary density in a mouse AMI model.
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