What is the clinical evidence from this study?

Study design: Other. Population: Myocardial infarction. Intervention: 17beta-estradiol vs. placebo. Primary outcome: Mobilization of endothelial progenitor cells and functional recovery from acute myocardial ischemia.

March 14, 2006CirculationOpen Access

Estradiol Enhances Recovery After Myocardial Infarction by Augmenting Incorporation of Bone Marrow–Derived Endothelial Progenitor Cells Into Sites of Ischemia-Induced Neovascularization via Endothelial Nitric Oxide Synthase–Mediated Activation of Matrix Metalloproteinase-9

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Key result

17beta-estradiol enhanced recovery after myocardial infarction in ovariectomized mice by augmenting the mobilization and incorporation of bone marrow-derived endothelial progenitor cells.

Why the study?

Does 17beta-estradiol improve recovery after myocardial infarction in ovariectomized mice?

Population

Ovariectomized mice with induced myocardial infarction via left coronary artery ligation

Comparison

17beta-estradiol vs Placebo

Design

Preclinical

Follow-up

up to 4 weeks

Authors

AIAtsushi IwakuraOsaka Red Cross Hospital SSShubha ShastryRochester General Hospital CLCorinne LuedemannRagon Institute of MGH, MIT and Harvard

Discussion

Member takes

Implication

Estradiol may enhance EPC neovascularization post-MI in mice; leaves open translation to human therapy.

Structured PICO

Does 17beta-estradiol improve recovery after myocardial infarction in ovariectomized mice?

Population

Ovariectomized mice with induced myocardial infarction.

Intervention

17beta-estradiol

Comparator

Placebo

Outcome

Mobilization and incorporation of bone marrow-derived endothelial progenitor cells (EPCs) into ischemic sites, capillary density, and functional recoverysurrogate

Estradiol enhances post-MI recovery by mobilizing bone marrow-derived EPCs via an eNOS- and MMP-9-dependent mechanism, providing insight into sex differences in cardiac events.

Cite This Study

Iwakura et al. (2006) studied Myocardial infarction. 17beta-estradiol vs. placebo was evaluated on Mobilization of endothelial progenitor cells and functional recovery from acute myocardial ischemia. 17beta-estradiol enhanced recovery after myocardial infarction in ovariectomized mice by augmenting the mobilization and incorporation of bone marrow-derived endothelial progenitor cells.

synapsesocial.com/papers/6a6ac47c01245da06ecb49cd https://doi.org/10.1161/circulationaha.105.553925

Topics

Women and heart disease

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Estradiol Enhances Recovery After Myocardial Infarction by Augmenting Incorporation of Bone Marrow–Derived Endothelial Progenitor Cells Into Sites of Ischemia-Induced Neovascularization via Endothelial Nitric Oxide Synthase–Mediated Activation of Matrix Metalloproteinase-9

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Estradiol Enhances Recovery After Myocardial Infarction by Augmenting Incorporation of Bone Marrow–Derived Endothelial Progenitor Cells Into Sites of Ischemia-Induced Neovascularization via Endothelial Nitric Oxide Synthase–Mediated Activation of Matrix Metalloproteinase-9

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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