September 16, 1997Circulation
Amelioration of Ischemia- and Reperfusion-Induced Myocardial Injury by 17β-Estradiol
Why the study?
Does 17beta-estradiol reduce infarct size and ventricular arrhythmia in dogs subjected to myocardial ischemia and reperfusion?
Population
Open-chest dogs subjected to myocardial ischemia and reperfusion
Comparison
17beta-estradiol (10 ng x kg x min) infused into… vs Control animals
Design
Preclinical
Follow-up
6 hours of reperfusion
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for estrogen cardioprotection in ischemia-reperfusion; leaves open translation to human myocardial infarction.
Structured PICO
Does 17beta-estradiol reduce infarct size and ventricular arrhythmia in dogs subjected to myocardial ischemia and reperfusion?
P
Population
Open-chest dogs subjected to myocardial ischemia (90 minutes' occlusion of the left anterior descending coronary artery) and reperfusion (6 hours)
I
Intervention
17beta-estradiol (10 ng x kg(-1) x min(-1)) infused into the coronary artery, initiated 10 minutes before coronary occlusion and continued until after 1 hour of reperfusion (excluding the occlusion period)
C
Comparator
Control animals
O
Outcome
Infarct size (as % of area at risk) and incidence of ventricular arrhythmiasurrogate
17beta-estradiol reduces myocardial infarct size and ischemia/reperfusion-induced ventricular arrhythmias in a canine model, mediated by NO and K(Ca) channels.
Cite This Study
Node et al. (1997) studied this question.