Why the study?
Does 17beta-estradiol improve reendothelialization and reduce medial thickening after arterial injury in ovariectomized mice?
Population
Ovariectomized wild-type mice and endothelial nitric oxide synthase-deficient mice with induced carotid…
Comparison
17beta-estradiol vs Placebo
Design
Preclinical
Follow-up
up to 21 days
Authors
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No clinical implications for human arterial injury; extends preclinical evidence on estradiol in ovariectomized models.
Does 17beta-estradiol improve reendothelialization and reduce medial thickening after arterial injury in ovariectomized mice?
Estradiol accelerates reendothelialization and reduces medial thickening after arterial injury via eNOS-dependent mobilization of bone marrow-derived endothelial progenitor cells.
Iwakura et al. (2003) studied this question.
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