June 17, 2003Circulation
Estrogen Increases Bone Marrow–Derived Endothelial Progenitor Cell Production and Diminishes Neointima Formation
Why the study?
Does estrogen replacement increase endothelial progenitor cell production and diminish neointima formation in estrogen-deficient models?
Population
Mice subjected to sham operation, ovariectomy, or ovariectomy and estrogen replacement treatment, as well as…
Comparison
Estrogen replacement treatment or increased… vs Sham operation or ovariectomy in mice
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for estrogen's vascular effects in animal injury models; leaves open translation to human restenosis prevention.
Structured PICO
Does estrogen replacement increase endothelial progenitor cell production and diminish neointima formation in estrogen-deficient models?
P
Population
Mice subjected to sham operation, ovariectomy, or ovariectomy and estrogen replacement treatment, as well as human women with increased estrogen plasma concentrations.
I
Intervention
Estrogen replacement treatment (in mice) or increased estrogen plasma concentrations (in humans)
C
Comparator
Sham operation or ovariectomy (estrogen deficiency) in mice
O
Outcome
Endothelial progenitor cell (EPC) levels (circulating, bone marrow-resident, and in vitro expanded), neointima formation after carotid artery injury, and reendothelializationsurrogate
Estrogens promote vascular repair and reduce neointima formation by increasing endothelial progenitor cells via antiapoptotic mechanisms.
Cite This Study
Strehlow et al. (2003) studied this question.