Key result
Cardiopulmonary bypass significantly increased plasma ET-1 levels compared with preoperative values (P<0.01).
Why the study?
Does cardiopulmonary bypass during coronary artery bypass surgery alter plasma endothelin-1 levels in adult patients?
Population
10 adult patients undergoing coronary artery bypass surgery (7 with stable angina, 3 with unstable angina)
Comparison
Coronary artery bypass surgery with… vs Preoperative baseline values
Design
Cohort
Follow-up
Perioperative period
Authors
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May signal endothelial injury risk in CABG; hypothesis-generating for ET-1 modulation trials.
Observational (n=10)
Does cardiopulmonary bypass during coronary artery bypass surgery alter plasma endothelin-1 levels in adult patients?
p-value: p=<0.01
Cardiopulmonary bypass during coronary revascularization significantly increases plasma endothelin-1 levels, which may contribute to sustained endothelial injury.
Rammos et al. (1996) conducted an observational in Coronary artery disease requiring coronary artery bypass surgery (n=10). Cardiopulmonary bypass vs. Preoperative values was evaluated on Plasma Endothelin-1 (ET-1) levels (p=<0.01). Cardiopulmonary bypass significantly increased plasma ET-1 levels compared with preoperative values (P<0.01).
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