Key result
Late gestation pregnancy was associated with a 3.5 to 4.5-fold increase in VLDL and IDL triglycerides and cholesterol, alongside decreased relative apo CII and increased apo CIII.
Why the study?
How do the relative amounts of apolipoproteins CII and CIII in VLDL and IDL change during late pregnancy compared to the postpartum period?
Observational
How do the relative amounts of apolipoproteins CII and CIII in VLDL and IDL change during late pregnancy compared to the postpartum period?
Pregnancy is associated with significant but reversible alterations in VLDL and IDL apolipoprotein C composition, which may affect triglyceride removal.
Answers are grounded in this paper and cite their sources.
Altered apo CII/CIII ratios may impair triglyceride clearance in late pregnancy; leaves open causal mechanisms and clinical relevance pending prospective data.
In vitro studies indicate that relative amounts of apolipoproteins CII and CIII in plasma may alter lipoprotein lipase mediated triglyceride removal from very low density lipoprotein. Therefore, we have determined relative amounts of these peptides in pregnant women in late gestation (mean 36 weeks) and 6 and 20 weeks postpartum. Very low density (d less than 1.006) and intermediate density (d 1.006-1.019) lipoproteins have been examined because they are affected similarly in pregnancy. Triglyceride and cholesterol in these two fractions increased 3 1/2 to 4 1/2-fold in pregnancy in keeping with previous reports. On a relative basis, apo CII was decreased and apo CIII1 and CIII2 increased in both VLDL and IDL at 36 weeks gestation. At 6 and 20 weeks postpartum relative amounts of C peptides returned to identical levels and were unaffected by lactation. It remains to be seen if in vivo triglyceride removal in pregnancy is altered by the reduction in apo CII relative to apo CIII.
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Montes et al. (1977) conducted an observational in Pregnancy. Late gestation pregnancy vs. 6 and 20 weeks postpartum was evaluated on Relative amounts of apolipoproteins CII and CIII in VLDL and IDL. Late gestation pregnancy was associated with a 3.5 to 4.5-fold increase in VLDL and IDL triglycerides and cholesterol, alongside decreased relative apo CII and increased apo CIII.
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