What question did this study set out to answer?

To determine how SET9 interacts with and methylates the androgen receptor and examine the downstream functional consequences in prostate cancer.

October 19, 2010The Medicine ForumOpen Access

Regulation of the androgen receptor by SET9-mediated methylation

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To determine how SET9 interacts with and methylates the androgen receptor and examine the downstream functional consequences in prostate cancer.
Assessed protein-protein interaction and direct methylation of the androgen receptor by the histone methyltransferase SET9.
Evaluated the impact of lysine 632 methylation on receptor domain communication, target gene recruitment, cancer cell proliferation, and apoptosis in prostate tissue.
SET9 directly methylated the androgen receptor at lysine 632, enhancing transcriptional activity by facilitating N- and C-terminal inter-domain communication and chromatin recruitment to androgen-target genes.
SET9 promoted proliferation, inhibited apoptosis in prostate cancer cells, and exhibited upregulated nuclear expression in prostate cancer tissue.

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Implication

Laboratory study demonstrates SET9-mediated methylation of the androgen receptor promotes prostate cancer cell growth, highlighting a novel therapeutic target.

Cite This Study

Gaughan et al. (2010) studied this question.

synapsesocial.com/papers/6a9f79cd63dc1fb3bd8923af https://doi.org/10.1093/nar/gkq861

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Implication

Laboratory study demonstrates SET9-mediated methylation of the androgen receptor promotes prostate cancer cell growth, highlighting a novel therapeutic target.

Regulation of the androgen receptor by SET9-mediated methylation

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Discussion

Implication

Cite This Study

Regulation of the androgen receptor by SET9-mediated methylation

Key Points

Discussion

Implication

Cite This Study

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