Key result
The evidence of beneficial effects of polyunsaturated fatty acids specific to patients with peripheral artery disease remains elusive.
Why the study?
Do polyunsaturated fatty acids provide beneficial effects in patients with peripheral artery disease?
Do polyunsaturated fatty acids provide beneficial effects in patients with peripheral artery disease?
The specific beneficial effects of polyunsaturated fatty acids in patients with peripheral artery disease remain elusive despite proven benefits in general secondary prevention.
There is substantial evidence that polyunsaturated fatty acids (PUFAs) such as n-3 and n-6 fatty acids (FAs) play an important role in prevention of atherosclerosis. In vitro and in vivo studies focusing on the interactions between monocytes and endothelial cells have explored the molecular effects of FAs on these interactions. Epidemiological surveys, followed by large, randomized, control trials have demonstrated a reduction in major cardiovascular events with supplementation of n-3 FAs in secondary prevention settings. The evidence of beneficial effects specific to patients with peripheral artery disease (PAD) remains elusive, and is the focus of this review.
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Grenon et al. (2012) conducted a review in Peripheral artery disease (PAD). Polyunsaturated fatty acids (PUFAs) was evaluated. The evidence of beneficial effects of polyunsaturated fatty acids specific to patients with peripheral artery disease remains elusive.
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