Key result
Reduced serum levels of docosahexaenoic acid (DHA) were significantly associated with the presence of infrainguinal lesions in patients with peripheral artery disease (OR 0.986).
Why the study?
Are serum levels of ω-3 PUFAs associated with disease location in patients with peripheral artery disease?
Cross-Sectional (n=98)
No
Are serum levels of ω-3 PUFAs associated with disease location in patients with peripheral artery disease?
Odds Ratio: 0.986 (95% CI 0.977–0.995)
p-value: p=0.003
This study aims to investigate the relationship between serum ω-3 PUFA levels and the anatomical location of peripheral artery disease.
Lower DHA levels associated with infrainguinal PAD lesions; hypothesis-generating for ω-3 role in lesion distribution and requires prospective validation.
Background: Recently, reduced serum levels of ω-3 polyunsaturated fatty acids (PUFAs) including docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), have been focused upon as newly recognized risk factors for peripheral artery disease (PAD). The present study investigated the association between disease location and serum levels of ω-3 PUFAs in patients with PAD.
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Iwasaki et al. (2018) conducted a cross-sectional in Peripheral Artery Disease (PAD) (n=98). Serum docosahexaenoic acid (DHA) levels was evaluated on Presence of infrainguinal lesions (OR 0.986, 95% CI 0.977-0.995, p=0.003). Reduced serum levels of docosahexaenoic acid (DHA) were significantly associated with the presence of infrainguinal lesions in patients with peripheral artery disease (OR 0.986).
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