Key result
A European-derived systolic blood pressure polygenic risk score was significantly associated with hypertension in admixed Brazilian cohorts (OR 1.28 in Baependi), though its predictive accuracy was reduced compared to European populations.
Why the study?
Although numerous genetic variants affecting SBP have been identified in European populations, their applicability in admixed populations remains unclear.
Does a European-based systolic blood pressure polygenic risk score accurately predict SBP and hypertension in diverse Brazilian cohorts?
Observational (n=80,021)
Yes
Does a European-based systolic blood pressure polygenic risk score accurately predict SBP and hypertension in diverse Brazilian cohorts?
European-based polygenic risk scores for systolic blood pressure have reduced predictive efficacy in admixed Brazilian populations, highlighting the need for diverse genetic data in risk prediction.
Answers are grounded in this paper and cite their sources.
SBP PRS from European data was associated with blood pressure in Brazilian cohorts; extends applicability to admixed populations but leaves clinical utility open.
Despite the identification of numerous genetic variants affecting SBP in European populations, their applicability in admixed populations remains unclear. This study evaluates the predictive efficacy of a systolic blood pressure (SBP) polygenic risk score (PRS), derived from the UK Biobank data, in two Brazilian cohorts. We analyzed 944 K genetic variants consistent across an independent UK Biobank dataset, Brazilian cohorts, and HapMap database. Results show a significant association between increased PRS and SBP, as well as hypertension, in each study groups analyzed. An increase of one standard deviation in the PRS showed a significant association with SBP (β [95% CI] (mmHg) = 5.2 [5.1-5.3], 2.8 [2.1-3.5] and 2.6 [2.2-3.0]) and hypertension (odds ratio (OR) [95% CI] = 1.56 [1.54-1.56], 1.28 [1.2-1.4] and 1.47 [1.3-1.6]) in an independent UKB dataset, Baependi, and Pelotas, respectively. The associations were weaker in the Brazilian samples and the reduced association was noticeable in the Pelotas vs. the UK comparison for hypertension stages 1 and 2 (OR [95% CI] = 2.1 [1.5-3.1] and 3.0 [1.9-4.7] vs. 2.5 [2.2-2.8] and 4.9 [4.4-5.6]), whereas the Baependi data showed no significance for stage 1 hypertension. This trend mirrors findings in homogeneous African and Asian populations with diverse genetic architecture, highlighting the limitations of European-based PRS also in admixed populations. These insights are crucial for developing tailored disease prevention and management strategies in ethnically diverse groups.
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Teixeira et al. (2024) conducted an observational in Hypertension (n=80,021). European-based systolic blood pressure polygenic risk score (PRS) vs. Lower polygenic risk score (per 1 standard deviation increase) was evaluated on Association of 1 standard deviation increase in PRS with hypertension in the Baependi cohort (OR 1.28, 95% CI 1.2-1.4, p=4.3 × 10-5). A European-derived systolic blood pressure polygenic risk score was significantly associated with hypertension in admixed Brazilian cohorts (OR 1.28 in Baependi), though its predictive accuracy was reduced compared to European populations.
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