A polygenic risk score in the highest 5 percentiles was associated with a 2.44-fold increased risk of hypertension and earlier onset by 8.5 years in Northeast Asians.
Does a high polygenic risk score for blood pressure increase the risk and predict earlier onset of incident hypertension in Northeast Asian individuals?
A polygenic risk score for blood pressure effectively identifies Northeast Asian individuals at high risk for incident and early-onset hypertension, potentially guiding earlier targeted lifestyle and medical interventions.
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Background Data on associations between genetic predisposition to high blood pressure (BP) and hypertension and its complications in non‐European populations are limited. The current study investigated associations between polygenic risk scores (PRSs) for BP and risks of hypertension, cardiovascular disease, and chronic kidney disease in Northeast Asian populations. Methods A genome‐wide association study of systolic BP (SBP) and diastolic BP (DBP) was conducted using data from the KoGES (Korean Genome and Epidemiology Study). Results were meta‐analyzed using summary statistics from Biobank Japan to construct PRSs. Results Compared with a PRS in the lowest 5 percentiles, a PRS in the highest 5 percentiles was associated with an increased risk of hypertension (hazard ratio HR, 2.44 95% CI, 1.67–3.56 for PRS for SBP; and HR, 1.77 95% CI, 1.20–2.62 for PRS for DBP) and earlier onset of hypertension (by a median of 8.5 years for PRS for SBP and 8.0 years for PRS for DBP). These associations remained significant when continuous PRS was analyzed. The genetic risk of hypertension incidence was attenuated by moderate to vigorous physical activity. Adding the PRS for BP to the clinical risk factors improved the predictive value for hypertension (both area under the curve values, 0.787 95% CI, 0.771–0.803; P =0.063 for PRS for SBP and 95% CI, 0.771–0.804; P =0.031 for PRS for DBP). However, neither PRS for SBP nor PRS for DBP was associated with the incidence of cardiovascular or chronic kidney disease. Conclusions The PRS for BP was associated with a higher risk of incident hypertension and earlier‐onset hypertension in a Northeast Asian population. PRS may facilitate early identification and targeted management of individuals at high risk of developing hypertension.
KIM et al. (Tue,) reported a other. A polygenic risk score in the highest 5 percentiles was associated with a 2.44-fold increased risk of hypertension and earlier onset by 8.5 years in Northeast Asians.
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