Key result
Phylogenetic and Simplot analyses revealed that the Echo7 strain DH22G/JS/2012, isolated from a child with hand, foot, and mouth disease in mainland China, is a recombinant coxsackievirus B4.
Case Report (n=1)
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The Echo7 strain DH22G/JS/2012 associated with HFMD in mainland China is a recombinant coxsackievirus B4, highlighting the evolutionary dynamics of these viruses.
To investigate the evolution of echovirus 7 (Echo7) strains and the relationship between Echo7 strains and the prototype strain Wallace, phylogenetic analysis of Echo7 strains prevailing in mainland China was performed. The Echo7 strain, DH22G/JS/2012 was isolated from a 32-month-old boy who was clinically diagnosed with HFMD. The complete genome sequence of this isolate was determined after the virus was propagated in cell culture. Phylogenetic analysis showed that the subgroups B1 and C1 prevailed in mainland China from 1998 to 2012 and that the subgroup B2 began to circulate in mainland China in 2009. The result of Simplot analysis showed that the Echo7 strain DH22G/JS/2012 is a recombinant coxsackievirus B4 (CVB4) that circulated in mainland China in 2010.
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Yao et al. (2015) conducted a case report in Hand, foot, and mouth disease (HFMD) (n=1). Echovirus 7 (Echo7) infection was evaluated on Complete genome sequence and phylogenetic analysis of the isolated Echo7 strain. Phylogenetic and Simplot analyses revealed that the Echo7 strain DH22G/JS/2012, isolated from a child with hand, foot, and mouth disease in mainland China, is a recombinant coxsackievirus B4.
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