Key result
Hypothetical prevention of all out-of-hospital cardiac deaths prolonged life by 0.63 years (95% CI 0.49-0.77) after the first heart failure admission, dropping to 0.28 years after 3 admissions.
Why the study?
Does the hypothetical prevention of sudden death (simulating ICD use) significantly prolong life in patients with repeated hospital admissions for heart failure?
Cohort (n=14,374)
Does the hypothetical prevention of sudden death (simulating ICD use) significantly prolong life in patients with repeated hospital admissions for heart failure?
Mean Difference: 0.63 (95% CI 0.49–0.77)
The maximum potential survival benefit of implantable defibrillators is limited in older patients with comorbidities and multiple heart failure hospitalizations.
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Limited survival gain from preventing sudden death after repeated HF admissions; leaves open ICD benefit in multimorbid patients.
Setoguchi et al. (2009) conducted a cohort in Heart failure (n=14,374). Hypothetical prevention of all out-of-hospital cardiac deaths vs. Observed survival was evaluated on Prolongation of life after the first hospital admission (MD 0.63 years, 95% CI 0.49 to 0.77). Hypothetical prevention of all out-of-hospital cardiac deaths prolonged life by 0.63 years (95% CI 0.49-0.77) after the first heart failure admission, dropping to 0.28 years after 3 admissions.
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