Key result
The AA allele for the caspase-1 SNP rs501192 was more frequent in T. cruzi infected patients with cardiomyopathy compared to those with normal cardiac status (OR -2.18, p=0.117).
Why the study?
Do caspase-1 polymorphisms associate with the development of Chagas cardiomyopathy in Trypanosoma cruzi infected individuals?
Cross-Sectional (n=236)
No
Do caspase-1 polymorphisms associate with the development of Chagas cardiomyopathy in Trypanosoma cruzi infected individuals?
The caspase-1 SNP rs501192 AA allele showed a non-significant trend towards higher frequency in patients with Chagas cardiomyopathy, suggesting a potential genetic marker for disease progression.
Should not change clinical management; leaves open whether caspase-1 rs501192 influences Chagas cardiomyopathy risk.
INTRODUCTION:: Trypanosoma cruzi (Tc) infection is usually acquired in childhood in endemic areas, leading to Chagas disease, which progresses to Chagas cardiomyopathy in 20-30% of infected individuals over decades. The pathogenesis of Chagas cardiomyopathy involves the host inflammatory response to T. cruzi, in which upstream caspase-1 activation prompts the cascade of inflammatory chemokines/cytokines, cardiac remodeling, and myocardial dysfunction. The aim of the present study was to examine the association of two caspase-1 single nucleotide polymorphisms (SNPs) with cardiomyopathy. METHODS:: We recruited infected (Tc+, n = 149) and uninfected (Tc-, n = 87) participants in a hospital in Santa Cruz, Bolivia. Cardiac status was classified (I, II, III, IV) based on Chagas cardiomyopathy-associated electrocardiogram findings and ejection fractions on echocardiogram. Genotypes were determined using Taqman probes via reverse transcription-polymerase chain reaction of peripheral blood DNA. Genotype frequencies were analyzed according to three inheritance patterns (dominant, recessive, additive) using logistic regression adjusted for age and sex. RESULTS:: The AA allele for the caspase-1 SNP rs501192 was more frequent in Tc+ cardiomyopathy (classes II, III, IV) patients compared to those with a normal cardiac status (class I) [odds ratio (OR) = -2.18, p = 0.117]. This trend approached statistical significant considering only Tc+ patients in class I and II (OR = -2.64, p = 0.064). CONCLUSIONS:: Caspase-1 polymorphisms may play a role in Chagas cardiomyopathy development and could serve as markers to identify individuals at higher risk for priority treatment.
No takes yet. Share an insight, caveat, or question.
Fu et al. (2017) conducted a cross-sectional in Chagas cardiomyopathy (n=236). Caspase-1 SNP rs501192 AA allele vs. Normal cardiac status (class I) / other alleles was evaluated on Chagas cardiomyopathy (classes II, III, IV) vs normal cardiac status (class I) in Tc+ patients (OR -2.18, p=0.117). The AA allele for the caspase-1 SNP rs501192 was more frequent in T. cruzi infected patients with cardiomyopathy compared to those with normal cardiac status (OR -2.18, p=0.117).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: