Key result
Homozygosity for LTA +80C and +252G alleles is linked to higher chronic Chagas cardiomyopathy prevalence.
Why the study?
Do polymorphisms in the lymphotoxin-alpha (LTA) gene predispose to chronic Chagas cardiomyopathy in T. cruzi-infected patients?
Case-Control (n=245)
Do polymorphisms in the lymphotoxin-alpha (LTA) gene predispose to chronic Chagas cardiomyopathy in T. cruzi-infected patients?
Absolute Event Rate: 47% vs 33%
Polymorphisms in the lymphotoxin-alpha gene (LTA +80C and +252G alleles) are associated with an increased susceptibility to developing chronic Chagas cardiomyopathy in T. cruzi-infected individuals.
No takes yet. Share an insight, caveat, or question.
LTA homozygosity may mark genetic susceptibility to Chagas cardiomyopathy; hypothesis-generating and requires prospective validation before any clinical use.
Ramasawmy et al. (2007) conducted a case-control in Chronic Chagas Cardiomyopathy (n=245). LTA +80C and LTA +252G polymorphisms vs. Absence of polymorphisms was evaluated on Homozygosity for LTA +80C. Homozygosity for the LTA +80C and LTA +252G alleles was significantly more frequent in patients with chronic Chagas cardiomyopathy than in asymptomatic patients (47% vs 33% and 16% vs 8%).
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