Key result
The rs640249 polymorphism in the ACTC1 gene is significantly associated with susceptibility to chronic Chagas cardiomyopathy (OR 1.47).
Why the study?
Does polymorphism in the ACTC1 gene increase susceptibility to chronic Chagas cardiomyopathy in T. cruzi-infected patients?
Case-Control (n=571)
Yes
Does polymorphism in the ACTC1 gene increase susceptibility to chronic Chagas cardiomyopathy in T. cruzi-infected patients?
Odds Ratio: 1.47 (95% CI 1.11–1.93)
p-value: p=0.006
Genetic variations in the ACTC1 gene, particularly the rs640249 polymorphism, may increase susceptibility to developing chronic Chagas cardiomyopathy in T. cruzi-infected individuals.
No takes yet. Share an insight, caveat, or question.
Should not yet inform risk stratification; hypothesis-generating for ACTC1 variants and requires replication.
Frade et al. (2013) conducted a case-control in Chronic Chagas cardiomyopathy (n=571). ACTC1 gene polymorphism (rs640249) vs. Asymptomatic T. cruzi-infected individuals was evaluated on Susceptibility to chronic Chagas cardiomyopathy (OR 1.47, 95% CI 1.11-1.93, p=0.006). The rs640249 polymorphism in the ACTC1 gene is significantly associated with susceptibility to chronic Chagas cardiomyopathy (OR 1.47).
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