Cryptococcal meningitis

ing the ictal and post ictal periods. The heightened capillary permeability could explain the focal enhancing lesions when the seizures are frequent. Return to normal permeability in a seizures free period, after treatment, could be the reason for the lack of extravasation of the contrast material into the parenchyma and therefore of the nonvisualisation of the epileptic focus on repeat CT scan. Recent studies performed in epileptic patients by positron emission tomography (PET) showed modification of the local cerebral blood flow and metabolism during the ictal and interictal periods.5 With further development PET probably will help in elucidating this phenomenon and the basic mechanisms of epilepsy.