Key result
A small plaque mutant of polyoma virus is temperature-sensitive for virus DNA synthesis at 41.5°C, yet induces cellular DNA synthesis, allowing virus-transformed cells to multiply at high temperatures.
Separates viral from cellular DNA synthesis in polyoma transformation; leaves open relevance to human oncogenesis.
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
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Ossovski et al. (1967) studied Polyoma virus infection and cell transformation. High temperature incubation (41.5°C or 41°C) vs. Incubation at 37°C was evaluated on Virus yield, infectious DNA synthesis, and cell multiplication. A small plaque mutant of polyoma virus is temperature-sensitive for virus DNA synthesis at 41.5°C, yet induces cellular DNA synthesis, allowing virus-transformed cells to multiply at high temperatures.
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