Gene with Quantitative Effect on Circulating Interferon Induced by Newcastle Disease Virus

Circulating interferon production, induced by Newcastle disease virus, is about seven times higher in C(57) Black mice than i Balb/c/Gif mice. A Mendelian analysis was carried out and circulating interferon production was measured in reciprocal F(1) hybrids, in the F(2) generation, in progeny of backcrosses of F(1) hybrids to either parent strain, and in second backcross progeny. The results indicate that a single, partly dominant, autosomal factor is responsible for the difference in circulating interferon production between both parent strains.