Key result
Brachial-ankle pulse wave velocity was significantly inversely correlated with lower extremity sensory nerve conduction parameters in diabetic patients (superficial peroneal SNAP r=-0.466, p<0.05).
Why the study?
Is brachial-ankle pulse wave velocity associated with nerve conduction study parameters in diabetic patients?
Observational (n=100)
Is brachial-ankle pulse wave velocity associated with nerve conduction study parameters in diabetic patients?
Effect estimate: r = -0.466
p-value: p=<0.05
Systemic arterial stiffness, as measured by baPWV, is inversely correlated with peripheral nerve function in diabetic patients.
May associate arterial stiffness with diabetic neuropathy; hypothesis-generating and requires longitudinal studies before clinical implications.
BACKGROUND/AIMS: Brachial-ankle pulse wave velocity (baPWV) is a marker of vascular stiffness and is reported to be associated with diabetic neuropathy; however, the relationship between baPWV and nerve conduction study (NCS) has yet to be examined. METHODS: Between January 2006 and December 2008, we investigated this relationship in diabetic patients. To this end, we reviewed the medical records of 100 diabetic patients for whom both baPWV and NCS had been examined. RESULTS: The mean age of patients was 55.4 ± 10.6 years, and the mean duration of diabetes mellitus was 6.3 ± 7.3 years. A statistically significant inverse correlation between baPWV and NCS was observed, especially in the lower extremity sensory NCS [superficial peroneal sensory nerve action potential (SNAP), r = -0.466, p <0.05; sural SNAP, r = -0.384, p <0.01]. A multiple linear regression analysis also demonstrated a significant association between baPWV and some parameters of NCS (SNAP of sural nerve, and nerve conduction velocity of peroneal and sural nerves). CONCLUSION: These results indicate that the degree of systemic arterial stiffness is associated with peripheral nerve status in diabetic patients, but it is unclear what this signifies and further study is needed.
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Suh et al. (2010) conducted an observational in Diabetes mellitus (n=100). Brachial-ankle pulse wave velocity (baPWV) was evaluated on Correlation between baPWV and nerve conduction study (NCS) parameters (r = -0.466, p=<0.05). Brachial-ankle pulse wave velocity was significantly inversely correlated with lower extremity sensory nerve conduction parameters in diabetic patients (superficial peroneal SNAP r=-0.466, p<0.05).
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