Key result
Patients with acute myocardial infarction and metabolic syndrome had significantly lower levels of serum vitamin C (0.65 vs 1.29 mg/dL) and vitamin E (0.81 vs 1.40 mg/dL) compared to healthy controls.
Why the study?
Are non-enzymatic antioxidant levels (vitamin E and C) decreased in AMI patients with metabolic syndrome compared to healthy controls?
Case-Control (n=100)
No
Are non-enzymatic antioxidant levels (vitamin E and C) decreased in AMI patients with metabolic syndrome compared to healthy controls?
Absolute Event Rate: 0.65% vs 1.29%
p-value: p=<0.001
AMI patients with metabolic syndrome exhibit significantly decreased levels of non-enzymatic antioxidants (vitamin E and C), suggesting increased oxidative stress.
Altered antioxidant markers in AMI with metabolic syndrome; hypothesis-generating and should not yet change practice.
BACKGROUNDThe present study was conducted to know the changes in markers of non-enzymatic antioxidant capacity in Acute Myocardial Infarction (AMI) patients with metabolic syndrome abnormalities. MATERIALS AND METHODSThe study included 50 diagnosed cases of AMI with metabolic syndrome abnormalities and 50 healthy controls.Fasting blood samples were collected and plasma sugar, serum triglycerides, serum HDL-C and non-enzymatic antioxidants -serum vitamin E, vitamin C, blood pressure and waist-circumference were estimated in all the subjects.Statistical Analysis-It was performed using the unpaired student 't' test to evaluate the significance of differences between the mean values.P-values less than 0.001 were considered as highly significant. RESULTSA highly significant increase was observed in levels of plasma sugar and triglycerides, blood pressure and waist-circumference whereas a highly significant decrease levels were observed in serum HDL-C, vitamin E and vitamin C in patients as compared with control group. CONCLUSIONOxidative stress is a potential contributor to AMI besides metabolic syndrome.On the basis of our results, it may be concluded that the non-enzymatic antioxidants -vitamin E and vitamin C decreased in the patients.
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Devi et al. (2016) conducted a case-control in Acute Myocardial Infarction with metabolic syndrome (n=100). Acute myocardial infarction with metabolic syndrome vs. Healthy controls was evaluated on Serum Vitamin C (mg/dL) (p=<0.001). Patients with acute myocardial infarction and metabolic syndrome had significantly lower levels of serum vitamin C (0.65 vs 1.29 mg/dL) and vitamin E (0.81 vs 1.40 mg/dL) compared to healthy controls.
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