Key result
Patients with a history of myocardial infarction had significantly lower levels of oxidized low-density lipoprotein compared to controls without prior cardiovascular events (p=0.02).
Why the study?
Obesity promotes atherosclerosis and increases reactive oxygen species, prompting evaluation of oxidative/antioxidative status and its correlation with anthropometric parameters and body composition after myocardial infarction versus in individuals without past cardiovascular events.
Case-Control (n=160)
p-value: p=0.02
Total oxidative/antioxidative status is related to the amount and visceral distribution of adipose tissue in both post-myocardial infarction patients and individuals without prior cardiovascular events.
Should not change clinical practice; leaves open the prognostic value of oxLDL after MI.
Obesity is one of the factors leading to the development of atherosclerosis. This metabolic disorder is associated with an increased production of reactive oxygen species, which affect the oxidative stress levels. The aim of this study was to evaluate oxidative/antioxidative status and to investigate the correlation between redox markers and anthropometric parameters and body composition in adult patients after myocardial infarction and in individuals without a cardiovascular event in the past. Descriptive data on socio-demographic, clinical, and anthropometric features and blood samples were collected and categorized into two equal groups: after myocardial infarction (study group (SG), n = 80) and without a cardiovascular event (control group (CG), n = 80). The oxidative/antioxidative status was assessed in plasma on the basis of total oxidative/capacitive status (PerOx), total antioxidative status/capacity (ImAnOx), and oxidized low-density lipoprotein (oxLDL). The oxLDL was significantly higher in the CG group compared to the SG group (p = 0.02). No significant differences were found with regard to PerOx and ImAnOx values between the groups studied. A significant positive correlation between PerOx and percentage of adipose tissue (FM%) and body adiposity index (BAI) was found in the two studied groups. ImAnOx significantly positively correlated with visceral adiposity indexes(VAIs) in SG and FM% in CG. OxLDL negatively correlated with body mass index and waist to hip circumference ratio in CG. The total oxidative/antioxidative status is related to the amount of adipose tissue and the BAIs of the subjects. It was observed that it correlates more frequently with the visceral distribution of body fat.
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Nowicki et al. (2019) conducted a case-control in Myocardial Infarction (n=160). History of myocardial infarction vs. No history of cardiovascular events was evaluated on Oxidized low-density lipoprotein (oxLDL) levels (p=0.02). Patients with a history of myocardial infarction had significantly lower levels of oxidized low-density lipoprotein compared to controls without prior cardiovascular events (p=0.02).
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