Key result
In young subjects with acute myocardial infarction, oxidative stress markers were significantly increased at baseline and, although improved, remained altered after 12 months.
Observational (n=105)
Oxidative stress markers are significantly altered in young patients with acute myocardial infarction and remain abnormal even 12 months post-infarction.
Persistent oxidative stress post-MI in young patients may signal ongoing risk; hypothesis-generating and requires prospective trials before guiding care.
In 105 subjects (97 men and 8 women) aged <46 years (mean age 39.6 +/- 5.5 years), with recent acute myocardial infarction (T1), thiobarbituric acid reactive substances and total antioxidant status were determined; NO production was evaluated by measuring the nitrite and nitrate (NOx) concentration. The patients with acute myocardial infarction were subdivided according to the main risk factors, number of risk factors, and extent of coronary lesions. The evaluation was repeated after 12 months (T2). In these subjects, thiobarbituric acid reactive substances and NOx were significantly increased and total antioxidant status was significantly decreased at T1. In single risk factor, only NO metabolites were significantly lower in acute myocardial infarction subjects who smoke than in subjects who do not. Subdividing the subjects according to the number of risk factors and number of stenosed coronary vessels, there were no significant differences between the subgroups. At T2, thiobarbituric acid reactive substances and NOx were decreased and total antioxidant status was increased, but all parameters were still altered.
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Presti et al. (2007) conducted an observational in Acute myocardial infarction (n=105). Recent acute myocardial infarction vs. Baseline vs 12 months was evaluated on Thiobarbituric acid reactive substances, total antioxidant status, and NOx concentration. In young subjects with acute myocardial infarction, oxidative stress markers were significantly increased at baseline and, although improved, remained altered after 12 months.
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