Key result
Serum BNP shows no correlation with oxidative stress markers early after acute myocardial infarction.
Why the study?
The relationship between hemodynamic stress and oxidative stress during the early phase of acute myocardial infarction remains poorly understood.
Observational (n=110)
No
In patients with acute myocardial infarction, hemodynamic stress (BNP) and oxidative stress (MDA, SOD) markers undergo significant changes in the first 12 hours but do not correlate with each other, suggesting they represent distinct pathophysiological processes.
Background: Acute myocardial infarction (AMI) is one of the leading causes of morbidity and mortality worldwide. The condition is characterized by myocardial injury, ventricular dysfunction, and increased oxidative stress. B-type natriuretic peptide (BNP) is a well-established marker of ventricular wall stress, whereas malondialdehyde (MDA) and superoxide dismutase (SOD) reflect oxidative damage and antioxidant defense, respectively. However, the relationship between hemodynamic stress and oxidative stress during the early phase of AMI remains poorly understood. Objective: To evaluate the changes in serum BNP, MDA and SOD levels during the first 12 hours after hospital admission and to investigate the correlation between BNP and oxidative stress biomarkers in patients with acute myocardial infarction. Materials and Methods: This prospective observational study included 110 patients with confirmed acute myocardial infarction admitted to MGM Medical College and Hospital, Navi Mumbai, between August 2024 and April 2026. Venous blood samples were collected at the time of admission (At 0 hour) and At 12 hours after admission. Serum BNP levels were measured using enzyme-linked immunosorbent assay (ELISA), MDA levels were estimated by the Kei Satoh method, and SOD activity was determined using the Marklund and Marklund method. Biomarker levels at the two time points were compared using paired Student's t-test. Pearson's correlation analysis was performed to evaluate the relationship between BNP and oxidative stress biomarkers. A p-value of <0.05 was considered statistically significant. Results: Serum BNP levels increased significantly from at the time of admission to At 12 hours after admission (p < 0.0001), indicating worsening ventricular stress during the early phase of AMI. In contrast, MDA levels decreased significantly (p < 0.0001), while SOD activity increased significantly (p < 0.0001) over the same period, suggesting a reduction in oxidative stress and improvement in antioxidant defense following treatment. Despite these significant temporal changes, Pearson correlation analysis demonstrated no statistically significant relationship between BNP and either MDA or SOD at the time of admission or at 12 hours after admission (p > 0.05). Conclusion: Patients with acute myocardial infarction experience significant changes in both hemodynamic and oxidative stress biomarkers during the first 12 hours of hospitalization. However, BNP showed no significant correlation with MDA or SOD, indicating that ventricular stress and oxidative stress may represent distinct pathophysiological processes. Simultaneous assessment of these biomarkers may therefore provide complementary information for evaluating patients with acute myocardial infarction. https://doi.org/10.52783/jchr.v16.i4.16147
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saha (2026) conducted an observational in Acute myocardial infarction (n=110). Early phase of acute myocardial infarction vs. Time of admission (0 hours) was evaluated on Correlation between BNP and oxidative stress biomarkers (MDA and SOD) (p=>0.05). In patients with acute myocardial infarction, serum BNP levels showed no significant correlation with oxidative stress biomarkers MDA or SOD during the first 12 hours of admission (p > 0.05), despite significant independent temporal changes.
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