Key result
Troponin-T rises ~2-fold at 12 hours alongside key cardiac biomarkers in acute myocardial infarction.
Why the study?
Combining traditional cardiac biomarkers with novel biomarkers of hemodynamic stress and oxidative injury may enhance diagnostic and prognostic accuracy in acute myocardial infarction. This study evaluated the early kinetic changes and prognostic significance of Troponin-T, CK-MB, BNP, H-FABP, MDA, and SOD in AMI.
Do cardiac biomarkers (Troponin-T, CK-MB, BNP, H-FABP) and oxidative stress biomarkers (MDA, SOD) exhibit significant kinetic changes at 12 hours post-admission compared to baseline admission levels in patients with acute myocardial infarction?
Observational (n=92)
No
Do cardiac biomarkers (Troponin-T, CK-MB, BNP, H-FABP) and oxidative stress biomarkers (MDA, SOD) exhibit significant kinetic changes at 12 hours post-admission compared to baseline admission levels in patients with acute myocardial infarction?
In acute myocardial infarction, cardiac biomarkers (Troponin-T, CK-MB, BNP, H-FABP) and antioxidant SOD rise significantly within 12 hours of admission while lipid peroxidation marker MDA declines, supporting a multi-biomarker approach for early diagnosis and physiological tracking.
Early biomarker kinetics may refine AMI monitoring; hypothesis-generating for prognostic value and requires validation before practice change.
Background: Acute myocardial infarction (AMI) is a major cardiovascular emergency associated with myocardial necrosis, ventricular dysfunction, and oxidative stress.Early diagnosis and accurate prognostic assessment are essential for improving clinical outcomes.Combining traditional cardiac biomarkers with novel biomarkers reflecting hemodynamic stress and oxidative injury may enhance diagnostic and prognosti c accuracy in AMI.Aim: To evaluate the early kinetic changes and prognostic significance of cardiac biomarkers [Troponin-T, Creatine Kinase-MB (CK-MB), B-type Natriuretic Peptide (BNP), and Heart-type Fatty Acid-Binding Protein (H-FABP)] and oxidative stress biomarkers [Malondialdehyde (MDA) and Superoxide Dismutase (SOD)] in patients with acute myocardial infarction. Materials and Methods:This prospective observational study was conducted in the Department of Biochemistry in collaboration with the Departments of Cardiology and Emergency Medicine at MGM Medical College and Hospital, Navi Mumbai, from August 2024 to April 2026.A total of 92 patients diagnosed with acute myocardial infarction based on clinical findings, electrocardiographic changes, and biochemical parameters were included after obtaining informed consent.Blood samples were collected at admission (0 hour) and at 12 hours post -admission.Troponin-T was estimated by electrochemiluminescence, CK-MB by enzymatic kinetic method, BNP and H-FABP by ELISA, MDA by Kei Satoh method, and SOD by Marklund and Marklund method.Statistical analysis was performed using paired t-test, and p < 0.05 was considered statistically significant.Results: Significant increases were observed in serum Troponin-T, CK-MB, BNP, and H-FABP levels at 12 hours post-admission compared to admission (p < 0.0001).Oxidative stress biomarkers also demonstrated significant alterations, with a significant decrease in MDA levels and a significant increase in SOD activity at 12 ho urs postadmission compared to baseline values (p < 0.0001).Conclusion: Cardiac biomarkers and oxidative stress biomarkers exhibit significant early kinetic changes in acute myocardial infarction.H-FABP acts as an important ultra-early diagnostic biomarker, while BNP provides valuable prognostic information regarding ventricular stress and cardiac remodeling.Dynamic changes in MDA and SOD reflect oxidative injury and endogenous antioxidant recovery.A multi-biomarker approach integrating structural, neurohormonal, and oxidative stress markers may improve early diagnosis, risk stratification, and prognostic assessment in patients with acute myocardial infarction.
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A 2026 study conducted an observational in Acute Myocardial Infarction (n=92). 12 hours post-admission for acute myocardial infarction vs. Admission baseline (0 hour) was evaluated on Mean serum Troponin-T level (ng/L) (p=<0.0001). In acute myocardial infarction, cardiac biomarkers (Troponin-T, CK-MB, BNP, H-FABP) and SOD increased significantly at 12 hours while MDA decreased compared to admission (all p < 0.0001).
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