Key result
Young patients with acute myocardial infarction had significantly higher total oxidant status (17.33 vs 11.31 mmol/L) and oxidative stress index at admission compared to healthy controls.
Why the study?
Risk factors, clinical features, and prognosis of acute myocardial infarction differ in young patients, prompting evaluation of oxidative stress and its correlation with cardiac markers within 48 hours.
Case-Control (n=70)
No
Absolute Event Rate: 17.33% vs 11.31%
p-value: p=0.002
Oxidative stress markers TOS and OSI are elevated in young patients with AMI and show early correlation with cardiac enzymes, though their prognostic utility appears limited.
May inform oxidative stress assessment in young AMI; leaves open clinical utility pending prospective validation.
Objective: The relationship between oxidative stress and acute myocardial infarction has been shown in studies. Total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) reflect the oxidative balance. The risk factors, clinical features, and prognosis of acute myocardial infarction (AMI) in young patients differ from older counterparts. This study aims to determine the oxidative stress in the young acute AMI patients and its' correlation with cardiac markers within 48 hours by the quantitative measurement of TAS, TOS, and OSI. Material and Method: In this prospective, controlled study, we included 50 patients who were 45 years old or younger and diagnosed with AMI, as well as 20 healthy individuals as the control group. TOS and TAS were measured from venous blood samples via the spectrophotometric method. The oxidative stress index was obtained from these parameters. Results: Forty-five of totally 50 patients were male, and the mean age was (36±6.8). TOS and OSI values were found significantly higher than in the control group (p=0.002, p=0.005, respectively). TAS values were found not to be different from the control group (p=0.46). A significant correlation was found between CK 0. hour (h.), and TOS 0. h., CK-MB 0. h., and TOS 0. h., CK 48. h. and OSI 48. h., CK-MB 48. h. and OSI 48. h., respectively (r=0.36, p=0.008), (r=0.46, p=0.001), (r=0.32, p=0.03), (r=0.36, p<0.01). Conclusion: Oxidative stress increases in the early hours of AMI. The TOS and OSI values are correlated with cardiac markers at only some time points, and their prognostic values are limited in young AMI patients. TAS is not correlated with cardiac markers.
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Karabulut et al. (2021) conducted a case-control in Acute Myocardial Infarction (n=70). Acute Myocardial Infarction vs. Healthy individuals was evaluated on Total oxidant status (TOS) at admission (p=0.002). Young patients with acute myocardial infarction had significantly higher total oxidant status (17.33 vs 11.31 mmol/L) and oxidative stress index at admission compared to healthy controls.
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