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September 1, 1963Journal of Clinical InvestigationOpen Access

Alterations in the Fatty Acid Composition of Human Lymph and Serum Lipoproteins by Single Feedings*

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Key result

Single feedings of corn or coconut oil markedly altered the fatty acid composition of human thoracic duct chylomicrons to almost identically resemble the ingested fat within 6 to 8 hours.

Why the study?

Does a single feeding of corn oil or coconut oil alter the fatty acid composition of human lymph and serum lipoproteins in adult males?

Population

3 male patients: a 64-year-old with inoperable lung carcinoma, a 54-year-old with chronic alcoholism and…

Comparison

Single feeding of 100 g of corn oil or coconut… vs Fasting state (baseline).

Design

Case_series

Follow-up

48 hours

Authors

HKHerbert J. KaydenUniversité Libre de BruxellesAKArthur KarmenYeshiva UniversityADAllan E. DumontSupélec

Discussion

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Implication

Supports direct dietary fat effects on chylomicrons; leaves open clinical relevance pending controlled trials.

Structured PICO

Does a single feeding of corn oil or coconut oil alter the fatty acid composition of human lymph and serum lipoproteins in adult males?

P
Population
3 adult men (ages 39-64) with various underlying conditions who received single feedings of dietary fats to study lipoprotein composition.
I
Intervention
Single feeding of 100 g of corn oil or coconut oil mixed in 250 ml of fruit juice.
C
Comparator
Fasting state (baseline).
O
Outcome
Fatty acid composition of human thoracic duct chyle lipoproteins and serum lipoproteins.surrogate

Single feedings of specific fats rapidly and directly alter the fatty acid composition of human chylomicrons and, to a lesser extent, other serum lipoproteins.

Limitations

  • Very small sample size of only 3 patients
  • Patients had severe underlying diseases (carcinoma, alcoholism, pneumonia) that could affect lipid metabolism
  • Lack of dietary control prior to or during the study

Cite This Study

Kayden et al. (1963) studied Various (lung carcinoma, alcoholism/pancreatitis, pneumonia) (n=3). Single feeding of corn oil or coconut oil vs. Fasting state (baseline) was evaluated on Fatty acid composition of thoracic duct chyle and serum lipoproteins. Single feedings of corn or coconut oil markedly altered the fatty acid composition of human thoracic duct chylomicrons to almost identically resemble the ingested fat within 6 to 8 hours.

synapsesocial.com/papers/6a9f99e53c7dd4a1896903d5https://doi.org/10.1172/jci104821
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1THE ABSORPTION OF FATS STUDIED IN A CHILD WITH CHYLOTHORAX1955 · 75 citations
  2. 2Qualitative microanalysis and estimation of sphingolipid bases1959 · 350 citations
  3. 3Technic for Collection of Thoracic Duct Lymph of Man1958 · 46 citations