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). The intrinsic blood coagulation pathway was clearly strengthened by the unique interface of Ca-biosilica, which was rich in silanol groups and calcium, leading to fast hemorrhage control in rat-tail amputation model. The clotting time of Ca-biosilica was 88.34 ± 28.54 s, which was similar to that of Quickclot® zeolite, whereas only one-third blood loss by weight (0.21 ± 0.16 g) was found in Ca-biosilica-treated group compared with that of the Quickclot® zeolite group (0.63 ± 0.09 g). The results prove that Ca-biosilica is promising as a quick hemostatic agent due to its effectiveness, excellent biocompatibility and simple and environmentally friendly preparation process.
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Li et al. (2018) studied this question.
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