Key result
Increased platelet-aggregation-enhancing activity in the plasma of adult diabetics correlates with the severity of diabetic retinopathy, suggesting a potential preventive role for aspirin.
Why the study?
Does aspirin prevent diabetic retinopathy in adult diabetics?
Observational
Does aspirin prevent diabetic retinopathy in adult diabetics?
Increased platelet aggregation may play a significant role in the genesis of diabetic retinopathy, suggesting aspirin could be a potential preventive therapy.
Hypothesis-generating for aspirin in diabetic retinopathy; should not change practice without randomized trials.
An abnormal substance in the plasma of certain diabetic patients enhances platelet aggregation. There is a correlation between the severity of diabetic retinopathy and the degree of platelet-aggregationenhancing activity in the plasma of adult diabetics. We postulate that increased platelet aggregation leads to the development of ischemic retinal lesions and thereby plays a significant role in the genesis of diabetic retinopathy. Aspirin blocks the action of the aggregation-enhancing activity of diabetic plasma nonspecifically, although it has no effect on the plasma level of the factor. Therefore, therapy with aspirin may be of value in the prevention of diabetic retinopathy.
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Dobbie et al. (1974) conducted an observational in Diabetic retinopathy. Platelet-aggregation-enhancing activity was evaluated on Severity of diabetic retinopathy. Increased platelet-aggregation-enhancing activity in the plasma of adult diabetics correlates with the severity of diabetic retinopathy, suggesting a potential preventive role for aspirin.
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