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October 25, 2022International Journal of NutrologyOpen Access

Major evidence of nutrological regulation in obese patients with meta-inflammation: a systematic review

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Key result

Nutritional interventions including caloric restriction, antioxidant supplementation, and n-3 PUFA significantly reduce inflammatory markers such as C-reactive protein, TNF-alpha, and IL-6 in obese patients.

Why the study?

To highlight clinical considerations of nutrological and dietary regulation in obese patients with marked inflammatory processes and meta-inflammation.

Does nutrological and dietary regulation improve inflammatory and metabolic markers in obese patients with meta-inflammation?

Population

Obese patients with marked inflammatory processes and meta-inflammation across 29 included studies

Comparison

Nutrological and dietary regulation vs controls or baseline

Design

Systematic review

Authors

PLPaulo Mageste LessaKLKarla Dias Barbosa LessaBOBruno de Souza Oliveira

Discussion

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Overview

Supports antioxidant and n-3 PUFA supplementation to improve markers in obese patients; extends evidence for dietary interventions in meta-inflammation.

Study Design

Type

Systematic Review (n=29)

Structured PICO

Does nutrological and dietary regulation improve inflammatory and metabolic markers in obese patients with meta-inflammation?

P
Population
A systematic review of 29 studies evaluating the effects of nutrological and dietary regulation in obese patients with meta-inflammation.
I
Intervention
Nutrological and dietary regulation, including caloric restriction, antioxidant supplementation, and n-3 PUFA supplementation
C
Comparator
Placebo (for supplementation studies) or unbalanced dietary patterns (e.g., Western diet)
O
Outcome
Inflammatory markers (PCR, TNF-alpha, IL-6), anthropometric measures (BMI, waist circumference), and metabolic parameters (fasting blood glucose, insulin resistance, lipids)surrogate

Dietary interventions, including caloric restriction and supplementation with antioxidants or n-3 PUFAs, can improve metabolic and inflammatory profiles in obese patients.

Limitations

  • High risk of bias in many initially identified studies (32 excluded for high risk of bias)
  • Many studies did not meet GRADE criteria (25 excluded)
  • High risk of bias in many evaluated studies
  • Many studies did not meet GRADE quality standards

Cite This Study

Lessa et al. (2022) conducted a systematic review in Obesity with meta-inflammation (n=29). Nutritional regulation (caloric restriction, antioxidants, n-3 PUFA) vs. Unbalanced dietary patterns or placebo was evaluated on Inflammatory markers and metabolic parameters. Nutritional interventions including caloric restriction, antioxidant supplementation, and n-3 PUFA significantly reduce inflammatory markers such as C-reactive protein, TNF-alpha, and IL-6 in obese patients.

synapsesocial.com/papers/6a9fa50d1f0ba8eae6bab3e5https://doi.org/10.54448/ijn22307
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nutrological management of meta-inflamation in patients with obesity: a systematic review2025
  2. 2Effects of Nutritional Supplements on Inflammatory Biomarkers in Overweight and Obese Adults: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials2026
  3. 3The true cost of in-patient obesity: impact of obesity on inflammatory stress and morbidity2010 · 22 citations
  4. 4OBESITY AS A CHRONIC LOW-GRADE INFLAMMATORY DISEASE - PATHOPHYSIOLOGICAL MECHANISMS AND CLINICAL IMPLICATIONS. A REVIEW OF THE LITERATURE2026
  5. 5OBESITY AS AN IMMUNOMETABOLIC DISORDER: MECHANISMS OF IMMUNE IMPAIRMENT AND INCREASED SEVERITY OF INFECTIOUS DISEASES - A REVIEW OF CURRENT EVIDENCE2026