What does this research mean for the field?

Specific nutritional supplements, including probiotics combined with omega-3 fatty acids, synbiotics, green tea extract, and curcumin, significantly improve selected inflammatory biomarkers such as IL-6, TNF-α, and CRP in overweight and obese adults. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To assess and rank the comparative effects of 14 nutritional supplementation strategies on circulating inflammatory biomarkers in adults with overweight or obesity.

September 8, 2026NutrientsOpen Access

Effects of Nutritional Supplements on Inflammatory Biomarkers in Overweight and Obese Adults: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials

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Authors

ZCZhiyue Chen ALAiling Liu SBShuran Bian

Discussion

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Overview

Network meta-analysis reveals that specific supplements reduce systemic inflammation markers in overweight and obese adults, suggesting targeted nutraceutical options.

Key Points

To assess and rank the comparative effects of 14 nutritional supplementation strategies on circulating inflammatory biomarkers in adults with overweight or obesity.
Systematically searched PubMed, Embase, EBSCO, Web of Science, and the Cochrane Library for randomized controlled trials published between January 2000 and January 2026.
Conducted a frequentist random-effects network meta-analysis of 60 randomized controlled trials, reporting mean differences (MDs) with 95% confidence intervals (CIs) and ranking interventions using SUCRA alongside the CINeMA framework.
IL-6 levels were significantly reduced by green tea extract (MD = −2.57, 95% CI [−3.99, −1.15]) and curcumin (MD = −1.75, 95% CI [−2.74, −0.76]), while TNF-α was lowered by synbiotics (MD = −12.25, 95% CI [−16.7, −7.8]), probiotics with omega-3 (MD = −6.19, 95% CI [−9.12, −3.26]), and curcumin (MD = −2.59, 95% CI [−3.83, −1.35]).
CRP concentrations fell significantly with probiotics combined with omega-3 (MD = −1.74, 95% CI [−3.03, −0.46]), synbiotics (MD = −1.19, 95% CI [−1.85, −0.53]), zinc (MD = −1.18, 95% CI [−2.24, −0.11]), and curcumin (MD = −1.11, 95% CI [−2.14, −0.07]), while synbiotics markedly increased adiponectin (MD = 15.37, 95% CI [12.13, 18.61]).
No supplement achieved a statistically significant reduction in leptin levels, with exploratory meta-regression indicating that participant age, sex ratio, and concurrent exercise contributed to outcome heterogeneity.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6a9fd83b58e84d0ff5b4791c https://doi.org/10.3390/nu18172936

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September 8, 2026NutrientsOpen Access

Effects of Nutritional Supplements on Inflammatory Biomarkers in Overweight and Obese Adults: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials

View Full Paper

Ask AI

Bookmark

Authors

ZCZhiyue Chen ALAiling Liu SBShuran Bian

Discussion

Member takes

Overview

Network meta-analysis reveals that specific supplements reduce systemic inflammation markers in overweight and obese adults, suggesting targeted nutraceutical options.

Key Points

To assess and rank the comparative effects of 14 nutritional supplementation strategies on circulating inflammatory biomarkers in adults with overweight or obesity.
Systematically searched PubMed, Embase, EBSCO, Web of Science, and the Cochrane Library for randomized controlled trials published between January 2000 and January 2026.
Conducted a frequentist random-effects network meta-analysis of 60 randomized controlled trials, reporting mean differences (MDs) with 95% confidence intervals (CIs) and ranking interventions using SUCRA alongside the CINeMA framework.
IL-6 levels were significantly reduced by green tea extract (MD = −2.57, 95% CI [−3.99, −1.15]) and curcumin (MD = −1.75, 95% CI [−2.74, −0.76]), while TNF-α was lowered by synbiotics (MD = −12.25, 95% CI [−16.7, −7.8]), probiotics with omega-3 (MD = −6.19, 95% CI [−9.12, −3.26]), and curcumin (MD = −2.59, 95% CI [−3.83, −1.35]).
CRP concentrations fell significantly with probiotics combined with omega-3 (MD = −1.74, 95% CI [−3.03, −0.46]), synbiotics (MD = −1.19, 95% CI [−1.85, −0.53]), zinc (MD = −1.18, 95% CI [−2.24, −0.11]), and curcumin (MD = −1.11, 95% CI [−2.14, −0.07]), while synbiotics markedly increased adiponectin (MD = 15.37, 95% CI [12.13, 18.61]).
No supplement achieved a statistically significant reduction in leptin levels, with exploratory meta-regression indicating that participant age, sex ratio, and concurrent exercise contributed to outcome heterogeneity.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6a9fd83b58e84d0ff5b4791c https://doi.org/10.3390/nu18172936

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