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September 17, 2024Obesity ReviewsOpen Access

Effects of intermittent fasting and caloric restriction on inflammatory biomarkers in individuals with obesity/overweight: A systematic review and meta‐analysis of randomized controlled trials

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Authors

AAAhmad Bin AamirRKRoopa KumariRLRabia Latif

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Overview

Meta-analysis reveals caloric restriction and intermittent fasting lower distinct inflammatory biomarkers in overweight individuals, suggesting caloric restriction provides broader...

Key Points

  • To compare the effects of caloric restriction and intermittent fasting versus ad libitum feeding on circulating inflammatory markers in individuals with overweight or obesity.
  • Systematic search of PubMed, Web of Science, and SCOPUS for randomized controlled trials lasting at least 8 weeks.
  • Extracted outcomes for C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6).
  • Calculated standardized mean differences (SMDs) via fixed-effect meta-analysis with 'leave-one-out' sensitivity analyses.
  • Caloric restriction significantly reduced CRP (SMD −0.15 mg/L [95% CI −0.30 to −0.00], p = 0.04; I² = 0%) and IL-6 (SMD −0.31 pg/mL [95% CI −0.51 to −0.10], p = 0.004; I² = 73%).
  • Intermittent fasting significantly reduced TNF-alpha (SMD −0.32 pg/mL [95% CI −0.63 to −0.02], p = 0.04; I² = 44%).
  • Intermittent fasting showed no significant effect on CRP or IL-6, and caloric restriction showed no significant effect on TNF-alpha.

Cite This Study

Aamir et al. (2024) studied this question.

synapsesocial.com/papers/6a0932bd4c1e2db30bd2648chttps://doi.org/10.1111/obr.13838
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Effects of Intermittent Fasting on Inflammatory Markers in Adults: A Systematic Review and Pairwise and Network Meta-Analyses2025 · 12 citations
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  3. 3The Impact of Ramadan Fasting on Interleukin-6, Tumor Necrosis Factor-α, and C-Reactive Protein in Overweight and/or Obese and Non-Obese Individuals: A Systematic Review with Meta-Analysis2025
  4. 4Time-Restricted Eating Versus Daily Calorie Restriction: Effects on Inflammatory Markers over 12 Months in Adults with Obesity2025 · 4 citations
  5. 5Effects of Nutritional Supplements on Inflammatory Biomarkers in Overweight and Obese Adults: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials2026