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July 23, 2025NutrientsOpen Access

The Effects of Intermittent Fasting on Inflammatory Markers in Adults: A Systematic Review and Pairwise and Network Meta-Analyses

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Authors

MKMousa KhalafiAMAref Habibi MalekiSMShima Mojtahedi

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Overview

Systematic review shows intermittent fasting reduces certain inflammatory markers in adults, suggesting dietary implications for health.

Key Points

  • Intermittent fasting significantly reduced tumor necrosis factor (TNF-α) by 0.31, showing its potential benefits.
  • The analysis included 21 studies with a total of 839 participants, enhancing the reliability of the findings.
  • Time-restricted feeding (TRF) demonstrated the largest reduction in TNF-α, ranking highest for inflammatory markers.
  • Results suggest that different modes of intermittent fasting can influence inflammatory responses, highlighting dietary variations.

Cite This Study

Khalafi et al. (2025) studied this question.

synapsesocial.com/papers/689a061be6551bb0af8cdac1https://doi.org/10.3390/nu17152388
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of intermittent fasting and caloric restriction on inflammatory biomarkers in individuals with obesity/overweight: A systematic review and meta‐analysis of randomized controlled trials2024 · 23 citations
  2. 2Impact of Achieved Weight Loss by Intermittent Fasting Plus Early Time‐Restricted Eating and Calorie Restriction on Systemic and Adipose Tissue Markers of Inflammation in Adults at Risk of Type 2 Diabetes: An Exploratory Sub‐Study2025
  3. 3Intermittent fasting improves metabolic outcomes in metabolic syndrome: a systematic review and meta-analysis with GRADE evaluation2025 · 2 citations
  4. 4Intermittent Fasting: An Emerging Approach as an Inflammatory Control Strategy2024
  5. 5Intermittent fasting - its benefits and risks2025