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October 11, 2025Journal of Human Nutrition and Dietetics

Impact of Achieved Weight Loss by Intermittent Fasting Plus Early Time‐Restricted Eating and Calorie Restriction on Systemic and Adipose Tissue Markers of Inflammation in Adults at Risk of Type 2 Diabetes: An Exploratory Sub‐Study

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Authors

LTLaurent TurnerLZLijun ZhaoKLKai Liu

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Overview

Exploratory sub-study compares intermittent fasting and calorie restriction effects on inflammation in adults at risk of type 2 diabetes, highlighting weight loss impacts.

Key Points

  • Weight loss was significantly greater in groups using intermittent fasting and calorie restriction compared to standard care, emphasizing their potential benefits.
  • C-reactive protein levels decreased by 1.36 mg/dL and tumor necrosis factor α levels dropped by 0.082 pg/mL at month 6, indicating reduced inflammation.
  • The study involved 209 adults randomly assigned to intermittent fasting, calorie restriction, or standard care, assessing inflammatory markers over six months.
  • No significant differences in inflammatory gene expression were found in adipose tissue, suggesting similar outcomes regardless of weight loss intervention.

Cite This Study

Turner et al. (2025) studied this question.

synapsesocial.com/papers/68e9b1c9ba7d64b6fc1327aahttps://doi.org/10.1111/jhn.70137
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Time-Restricted Eating Versus Daily Calorie Restriction: Effects on Inflammatory Markers over 12 Months in Adults with Obesity2025 · 4 citations
  2. 2Effects of intermittent fasting and caloric restriction on inflammatory biomarkers in individuals with obesity/overweight: A systematic review and meta‐analysis of randomized controlled trials2024 · 23 citations
  3. 3The Effects of Intermittent Fasting on Inflammatory Markers in Adults: A Systematic Review and Pairwise and Network Meta-Analyses2025 · 12 citations
  4. 4The Effects of Time-Restricted Eating and Alternate-Day Modified Fasting on Interferon-γ and Interleukin-10 Levels in Young Asian Women with Obesity: A Quasi-Experimental Study2025
  5. 5Long-term Effects of Intermittent Fasting on Weight Loss and Metabolic Risk Factors: A Systematic Review of Randomized Controlled Trials2025