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May 8, 2026Nutrition Reviews

Efficacy of Different Modes of Intermittent Fasting for Decreasing Visceral and Subcutaneous Fat in Adults With Overweight and Obesity: A Systematic Review and Network Meta-analysis

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Authors

MKMousa KhalafiUniversity of KashanFGFaeghe GhasemiUniversity of GuilanMSMohammad Hossein SakhaeiShiraz University

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Implication

Systematic review evaluates effects of intermittent fasting on fat loss in overweight and obese adults, suggesting viable alternatives to caloric restriction.

Key Points

  • To evaluate the efficacy of different intermittent fasting interventions on reducing visceral and subcutaneous fat in adults with overweight and obesity.
  • Systematic review and network meta-analysis of randomized trials
  • Included studies on time-restricted eating, alternate-day fasting, and the 5:2 diet
  • Data from 24 studies (n=1930) assessing body mass index and fat changes were analyzed.
  • The 5:2 diet and time-restricted eating led to greater reductions in visceral fat compared to control (SMD -0.54 and -0.44 respectively)
  • Neither alternate-day fasting nor continuous caloric restriction showed significantly better outcomes for visceral fat
  • For subcutaneous fat, the 5:2 diet and time-restricted eating were more effective than control, but no method outperformed caloric restriction.

Cite This Study

Khalafi et al. (2026) studied this question.

synapsesocial.com/papers/69fd7e23bfa21ec5bbf06570https://doi.org/10.1093/nutrit/nuag064
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Also Consider

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  1. 1Effect of Intermittent Fasting on Anthropometric Measurements, Metabolic Profile, and Hormones in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis2025 · 9 citations
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  5. 5Visceral Adiposity and Cardiometabolic Risk: Clinical Insights and Assessment2025 · 24 citations