Key result
Subcutaneous administration of the angiotensin II type 1 receptor blocker valsartan at a sub-suppressor dose of 1 mg/kg per day did not inhibit cerebral aneurysm formation or inflammation in rat models.
Population
Rat models of cerebral aneurysm formation
Design
Preclinical
Authors
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Rat data challenge RAS blockade extension from aortic to cerebral aneurysms; hypothesis-generating and should not guide practice.
Absolute Event Rate: 1% vs 1.2%
Unlike in aortic aneurysms, the renin-angiotensin system and Angiotensin II type 1 receptor do not appear to play a major role in the formation of cerebral aneurysms in rat models.
Nishimura (2009) studied Cerebral aneurysm. Valsartan vs. Vehicle was evaluated on Internal elastic lamina (IEL) disruption score. Subcutaneous administration of the angiotensin II type 1 receptor blocker valsartan at a sub-suppressor dose of 1 mg/kg per day did not inhibit cerebral aneurysm formation or inflammation in rat models.
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