Key result
Primary aldosteronism was associated with higher baseline sympathetic nerve activity compared to normotensive controls (40 vs. 30 bursts/min, P=0.014), which decreased after unilateral adrenalectomy.
Why the study?
Does unilateral adrenalectomy reduce sympathetic nerve activity in patients with aldosterone-producing adenoma?
Population
14 hypertensive patients with biochemically proven primary aldosteronism, 20 patients with essential…
Comparison
Unilateral adrenalectomy vs Essential hypertension patients and normotensive…
Design
Cross-sectional
Follow-up
1 month
Authors
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May support reversible sympathetic overactivity after adrenalectomy in primary aldosteronism; hypothesis-generating and should not yet change practice.
Cross-Sectional (n=52)
Does unilateral adrenalectomy reduce sympathetic nerve activity in patients with aldosterone-producing adenoma?
Absolute Event Rate: 40% vs 30%
p-value: p=0.014
Primary aldosteronism is accompanied by sympathetic overactivity that is reversible following unilateral adrenalectomy, providing the first human evidence of this mechanism.
Kontak et al. (2010) conducted a cross-sectional in Primary aldosteronism (n=52). Primary aldosteronism vs. Normotensive controls and essential hypertension was evaluated on Muscle sympathetic nerve activity (SNA) (p=0.014). Primary aldosteronism was associated with higher baseline sympathetic nerve activity compared to normotensive controls (40 vs. 30 bursts/min, P=0.014), which decreased after unilateral adrenalectomy.
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